Are you using lots of Text objects? If so it may be related to https://www.scirra.com/forum/r190-global-layer-v-web-font-incompatibility_t120329.
How many layouts are you opening, exactly? If you open say 50 then it's hardly surprising it would end up using ~2GB RAM. Also are you using the 64-bit version of C2?
If you don't close the editor, but simply close the project and then re-open it, does that also improve it? (This will help identify if it's a per-project or per-editor instance issue)
It is going to be very difficult to do anything about a report like this without a minimal .capx; we could sign the NDA etc. but as per our bug report guidelines, completed projects generally aren't actually useful for bug reports anyway. It is far more useful if you can isolate the problem in a new project with simple steps to reproduce (e.g. doing one thing over and over), a bit like the way the other bug report isolated a hang to using lots of text objects followed by repeated previews - and then there's no need to sort out NDA paperwork either.