It depends too much on what you're doing with it. For example, with Spriter you could make smoothly animated giant bosses that would be completely impossible with full frame standard Construct sprites, and it would run very well on mobile.
Here is the basic platformer game engine running on my old Ipad Pro:
In this example, the player and trees in the first level are all Spriter based, as is the boss at the end of the video.
Also the entire main menu system is made in Spriter.
But you should always try your best to optimize and test your game often on real mobile devices frequently, no matter which (if any) plug-ins you use.
I would not recommend making every last particle effect a Spriter object, for example... simple things like collectible coins, explosions, shots etc are best left as regular construct sprites.