I have had this happen, too, with pixel data reverting when closing the animation editor. It was a while ago but I remember copy/pasting with selection tool.
More commonly, like Tokinsom mentioned, origin points move around after clicking a different anim/closing animation editor. This was more recent and common, and I know what I was doing (but didn't investigate) - I was copying single animation frames from the frame bar, then pasting into another existing Sprite's animation (usually a new animation), then adjust the origin point, then click a different anim/close animation editor...boom, sometimes origin point moves...or not...
I do wish we could report bugs that haven't been repro'd but are known or severe - e.g. I had reoccurring project corruption bug from Return Functions (since been fixed) but couldn't repro for months, so posted anyway, but was doomed to be closed and lost... Thankfully I figured the very specific way to trigger it (as you would with a project corrupting bug... Which turned out to be trivial to hotfix your project... Had I known).
I have a bug I really don't like, discovering it as I clean up a long-term project - deleting objects and reorganising their folders, saving often, sometimes the save fails once with a specific error, and then I KNOW what comes next - click save again, it will work this time, but close project, reopen, and project will fail to open due to a missing image file (often from an object NOT deleted). Thankfully console gives logs of exact files and can pull the image from backups. Only clue I noticed, is the filename differences sometimes, like some images end with 0001 but others don't (maybe due to it being a project from over 4 years).
LASTLY and I wonder if anyone else had this - moving a family into a folder, suddenly the family's events do not run (yes, in the project bar, just to organise your families).
Edit: Protip that helped me identify the obscure Return Function project corruption issue - use recording software like Nvidia Shadowplay that let's you hit a keyboard key to save the last 5 or 10 mins of whatever you were doing... Helped me retrace steps (although still difficult as the "trigger" of the bug may have happened far earlier or from something excruciatingly subtle).