Yeah, I guess once you have logic, it's just a language to learn.
So while the logical aspects will transfer over, you still must learn Object-Oriented programming techniques to really succeed. Unity is a component-based system and to make the most of it, you need to understand concepts like inheritance, polymorphism, encapsulation, abstraction, and how to use a strongly-typed api.
So while you can use the language and create things in a Construct-esque way, your game will suffer for it.
Unity is also a 3D engine, so you have to think about the Z axis even when doing a 2D game.
That being said, I find Unity to be an amazing tool for learning C# (i learned all the C# i know through Unity, and now work full time doing it), so I sincerely encourage the foray into new engines and new languages.