FYI all people who want it working : On the winehq support, they told me the file system (load/save and load license) works well on their test with R163 and wine 1.7.14.
I personnally don't use wine as they use it, I directly use the wine app from winebottler and it didn't work for me with 1.7.14 - I don't know why.
BUT, it works perfectly now with the latest 1.7.15 !
Only problem for now, I can't move/pan in the layout (The move/pan works only under crossover 13.1 but they don't support wine 1.7.15 yet).
For comparaison, The layout of Multimedia Fusion/Fusion 2.5 is working well, so I don't know what is the difference between the both workspaces (@Ashley if you can help on this, you may know what technology is using your workspace renderer, directx9, gdi.... ? I really don't know anything about this sorry).
Preview isn't working neither, and I'm pretty sure this is cause the wine bottle doesn't make the link to the mac localhost....