I was messing around with Blender 3D for 2D animations. It's not that difficult at all, but consumed a good time of mine, since i had to plan the cutouts, and learn about rigging, uv maps, weight painting... Anyway, i think it might be a good solution for spritesheets, or maybe for a realtime 2d skeletal animation (blender can export the whole thing as a .fbx file, dunno if it's possible to parse it back using Construct).
First test - Bending an arm using two bones and an armature deform:
Second test - A traditional walking cycle, using some old sketch i had here:
Hope you like it :)