Yeah condolent PS can get weird with it's timeline when animating sometimes.
Kuzie No Prob! PS is great, don't get me wrong. As long as you have created a set of pixel brushes, and your grid set up properly to streamline your workflow, it works. Though for pure creation I find Pyxeledit to be a bit easier and it retains proper pixel alignment when drawing. As in you don't get double pixels when drawing shapes or lines. It's more 'true' to pixel art.
I've seen http://www.piskelapp.com/ neat little app... Pickle looks sweet! I dig mirrored drawing abilities. Will have to check it out.
Aseprite - Great tool... Sadly I never liked it. :/ it's layout is very MS paint.