It might not be a good way if graphics cards commonly override the setting. You're best off using Set Display Resolution, zooming in, and setting Point sampling.
I have been doing this so far for most of my games. However it causes numerous problems. For example the placement of objects on Scroll Rate 0% layers will get messed up (it didn't do that in very old Construct versions btw). And eventually objects placed at the edge of the screen might be shy one pixel when zoomed, showing through the background. I guess that's why some people were importing their graphics double-sized to avoid the zoom.
So I'd really prefer using the window object like in this example, although the graphics card issue makes this method less recommendable. I'd love to just have a runtime option to make the game double-sized.
I have no way of knowing if this is the problem
just an idea to try
but for those having the problem
see in your graphics card settings if it's overwriting the application settings for anisotropic filtering
I checked my settings, but anisotropic filtering is set to application controlled. So I guess that isn't the cause.