When it comes to keeping your game running smoothly it helps to not go overboard on shaders and other effects.
If you can make your effects before-hand, you should. Like blurring a sprite in Photoshop before putting it into Construct, rather than using the Blur effect or something. Or using plain old color filters instead of Tint Plus when you can get away with it. Obviously you can't always do this, but just be on the lookout for any place you can cut down on GPU time.
Plus, while shaders are nice, a lot of people tend to overuse them anyway. Stacking five shaders on a sprite and topping things off with motion blur doesn't necessarily look good. Keep things slim, keep them subtle. A humble looking, yet good playing game is ten times better than a showcase of shader effects that runs really choppy.
Just my two cents, though.