Jagged when rotated

AFAIK Construct doesn't have "tile" style pixel rounding support, if that's what you're asking about.

Otherwise, jagged edges in pixel art is a given? Or I'm misunderstanding something.

This is what tile based pixel rounding looks like - youtu.be/CU4YjSZNTnY

And this is what normally happens, like in Construct. answers.unity.com/questions/725621/best-method-for-dealing-with-rough-sprite-edges-du.html

You'll need to decide whether you prefer point sampling (sample - nearest) or bilinear/trilinear filtering.

Honestly in my opinion players will generally not care either way. Avoid static objects at angles to minimize the issue, and it should be difficult to discern for objects in motion unless you're specifically looking for it. The human brain does a great job of smoothing out imperfections like this, especially if the gameplay is more engaging than studying the arrangement of pixels on the screen.

I never played the game Dandara, but looking at screenshot from steam it looks like they did have this issue as well. It might just be hard to see during fast pace gameplay.

As for the issue at hand, you could enlarge all the pixel art by x4 (as well as the viewport/layout, etc), then do the "crop" technique in the link you provided.