How do I trigger an event in this specific way?

This works, but it causes massive fps drops.

I want to make it so that it only triggers once when your cursor is hovering over a different tile on a tilemap.

Different tile or different tile position? either way, you could save that data after clicking in a variable and compare on click to the one you're currently on if it's the same as your variable ignore the command.

Maybe just try giving it a subevent that runs every .05 seconds and transfer your actions onto that subevent?

No, this is really inconvient and doesn't feel right.