1. Yes. Though you will need a wrapper program like CocoonJS
2. No, I don't think there is any problem. When exporting to CocoonJS everything is thrown into a zip file.
However sometimes you need to make a tweak here and there. As an example adding Clay.io requiers inserting files into the zip package. Or as of right now CocoonJS has screencanavas setting that will improve performance, but requires tweaking the C2runtime.js.
However, if not using Clay.io and not concerning(or instead wait until it's in) screencanvas. Then yes it's a very simple process.