Is it inefficient to use a big animated sprite

So i want to have something like 8 rooms in my level. The rooms are big (800,1440 pixels). Is it more efficient to use 8 different objects or use 8 instances of a sprite containing 50 or so frames, each frame being one room and set the frames when i need a different room? Does the number of frames influence performance? Even when they are not being used?

On start of layout all sprites used on this layout with all their animation frames are loaded into the memory.

So having a separate object for each layout is better for performance.