It looks like the effect "Replace Color" might be the way to go, it seems to include 255
Regarding performance i think the manual discourages this entire practice
Using too many effects can cause poor performance, especially on mobile devices. Try to only use effects when it is important to the appearance of the game.
Creating many instances of an object using effects can be very inefficient, since the effect must be processed repeatedly for small areas. If many instances need to use an effect, often it is more efficient to place all the instances on their own layer, and apply the effect to that layer instead. This can improve performance whilst producing the same visual appearance.
Never use effects to process a static effect on an object. For example, do not use the 'Grayscale' effect to make an object always appear grayscale. Instead apply the grayscale effect in an image editor and import a grayscale image to the object, without using any effects. This has the same visual result, and avoids performance-degrading effect processing. Effects like 'Grayscale' should only be used for transitions or making objects only occasionally appear grayscale.
For more information, see the manual section on performance tips.
It's not very clear to me, what it means by 'using too many effects. Whether that is too many different effects or too many objects with an effect applied to it. Thoughts?