I really appreciate the XML functionality in Construct 2, and so far it's working fantastically. On to the question:
I only use one XML file, and it is used extensively throughout the entire game. My question is, will I ever have to re-load it at any time during the game? Say, for example, The layout and event sheets change. Will the XML have to be re-loaded each time? I am also using AJAX in various places, if that makes any difference at all.
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No, it's global to the entire project, and it only ever loads anything when you use the 'Load' action.