I have a complex project , it worked everything with r165, then it's updated by r166, now the event stopped working for comparing instance variables for families. I made simple reproductions but they worked, it's very complicated to get this bug. It's not about game design and bad code, everything worked in r165.
Did you guys have some project using all type of instance variable from families and test with r166?
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Actually, I think found something, it was On animation finished trigger.
EDIT: Not only this animation event, some events cause breakpoints, It seems, it's a change break due to "Some further event engine optimisations, particularly aimed at making triggers faster to fire"
I cannot tell you the details, I'm sure it has do to something with group toggle events.