I changed my layout a little, clicked "Run Layout" the layout is still how it was? I never have had this issue before.
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I get this a lot on internet explorer, you need to force a refresh. Hit F5. It's about browser caching.
In cases where you might be using XML files, I find that they also sometimes get stuck in the browser cache. My solution there is either to wait for them to timeout (a few minutes) or else to switch to a different browser to see what happens.