C2 and W10 don't mix. Plain and simple. It most likely will never get fixed. Your best bet since your machine is powerful is running a VM with Windows 7, or dual boot. Neither is pleasant...but will work better if your intention is to use C2.
Some of the performance issues were addressed, but plenty outstanding as dop2000 pointed out.
There are other odd W10 behaviours I have seen which I did not get on W7, such as: image editor not loading (restart C2 fixes), exports get corrupted (restart C2 to fix), exported projects have artifacts in images (restart C2 to fix), sounds importing into "nothing" (restart C2 and reimport), copy and paste oddness, and lots of menus that fail to draw fast as dop2000 has experienced.
I am not bothering to report these issues. Not after the last bug report. Ashley closed the bug, even though it is not fixed. Ashley keeps getting the facts wrong on the bug, compiled together with all the other issues . . . Someone else will have to pick up the towel on this one. I mention this Methuselah, to emphasize your options (or lack of I suppose).
Basically, C2 does not support W10. Scirra may or may not say that, but it is the truth when you look at all the issues C2 had/has with W10 and given Scirras stance on it...it won't get fixed. Scirra should really post this somewhere officially, such as the Buy/Download page. These threads are going to just keep popping up more-and-more overtime (as more users switch to W10).
Tl:Dr; C2 is not supported by W10. It will work, but don't expect it to work flawless compared to running on W7. Your best bet is running a VM instance.
Edit: Edited for clarity