Best bet is to try a clean install.
Uninstall current C2, reboot, then move or delete (just move if you want to keep existing plugins) the remnants of the previous C2 installation. This is to clear out any possible corrupt or broken plugins.
If at all possible, see if there is any updates to your OS and graphics card.
Install either r168 or r171 and open one of the templates. Try duplicating a Layout.
If it still crashes, then there is more than likely something amiss with the OS or graphic drivers, but that would need a full OS rebuild to fully check, which is wouldn't be nice.
Others may have other ideas, but considering how many users use C2, and this hasn't been reported before, it's more than likely an issue with your system.