Having a 50MB project might cause issues while downloading your game - users might have to wait quite a bit of time, before they can play.
Several workarounds here:
1) If you are creating a multimedia-heavy game, consider releasing it as an executable with NodeWebkit/Cocoon etc.
2) Create a smart loader with a mini-game, that will keep the player busy until the main part downloads
3) For audio, use lower bitrates to keep file sizes smaller.
Your node-webkit solution will be *smaller* than the web-export, if you use a lot of sounds - as Node-Webkit only needs an OGG format, while regular web-export will have to keep wider compatibility and use multiple sound formats.