well i care more about the features tbh. It is way ahead of the other available options on construct2.
creature 2d runtime is very limited in terms of logic that you can setup with it. The author claims that this is due to construct2's limited sdk more than creature itself.
spriter runtime cant have deformable mesh sprites. No FFD or meshes. 2 has been in early alpha for over a year now.
spine2d runtime requires you to spend 300$ if you want deformable sprites and be tied to it's runtime's license - not very indie friendly. Also the runtime to software compatibility will break with updates.
Being open source and open standard is also a big feature that the other ones are missing in their strategies to lock the user to themselves via a license.
But I guess it all depends on how the runtime is implemented in construct2. It might as well end up being non finished and with limitations when on construct2.