I was following the old mentality: fully downloadable game and installer to "C:\games\". Is it out of question for Construct 2?
As it is, right out of the box, it isn't really.
Now there are ways you could still do it.
Wrappers were notified but are still not up to it.
A possible "better" solution could be to provide localhosting on the user's computer. Like he downloads/install a full archive, which is made of the exported project, a localhost executable (ex: mongoose introduced in the forum by chrisbrobs at first) and a .bat file (?) that will launch the mongoose executable as well as go to the local url, launching the default browser in the process.
It needs more refining to be a "working" solution, but I think the idea is there and you could very well, relying on the browser, have a local execution/application in the spirit you were talking about.