Nesteris are you saying it's a bad idea to do it in C2? I'd like to do it in Unity, but it's a lot for a one man programming team to do, which Is why I would like to do it in C2 to take away some overhead, and I've become pretty darn good at C2 as well.
Well aside from the fact that you can't make native apps in Construct 2 I'd say go for it.
Be warned though, performance will depend heavily upon NW.js working correctly, which itself depends on Chrome.
Also you can get random unfixable bugs from the underlying engine.
Performance is good, I'd say, at least for my game but I would heavily recommend that you make your game with something that uses actual code and exports true native instead of wrappers.
Ultimately it's up to you.
Word of advice if you choose C2, don't copy paste events, do them manually instead. This should eliminate one of the more dangerous random bugs.
C2 is without a doubt a wonderful engine, but it does have some severe limitations. Use what you're comfortable with and what you expect your target platforms to be. If you make a PC game and later decide to make it for a console, you're completely out of luck with C2.