Thank you for the replies! :)
I think if you use the right combinations of layout, layout sizes, window sizes, and some good edge detection you could probably get away with it
That said, C2 would work fine for a metroidvania.
Okay, so you don't think it would be a problem to make a metroidvania type of game in Construct 2?
I still haven't found anything that works like I want it to work when the player walks between layouts though. I want the player to be able to walk freely like in for example Castlevania games. But I would still want my event sheets to be at a minimum. The player should be able to for example jump through the end of a layout and still be in the jumping moment when entering to the next layout.
There used to be. Not so much anymore. Also if you're going to make a metroidvania you might want to look into building your own world editor - using layouts is not very practical regardless of which program you use, including GM and some others.
MadFactory, you said I shouldn't use layouts but instead build my own world editor. Could you elaborate on that? :) Or do you know a good tutorial that explains it?