Yes, you need append a parameter/string to the file name in the c2runtime.js script tag and change it when your file changes.
Locate this text in the "index.html" file
And change to something like this
The browser interprets the whole string as the file path even though what comes after the "?" are parameters. So next time you update your file just change the number in the script tag on your website
This will trick the browser into thinking it s new file and not used the cached file.