no need to replace, just change the frame number.
sprite1: frame 1: empty, frame 2: shorts, frame 3: jeans, frame 4: dress pants
sprite2: frame 1: empty, frame 2:tee shirt, frame 3: hoodie, frame 4: dress shirt
just make sure your sprite's animation speed is set to 0, otherwise it will play like an animation.
if they remove the clothing item, change to frame 0 (which is nothing)