What would run faster. To have a single large event sheet (250+ events) containing all the events for the game and have all the layouts reference the same event sheet or to have separate smaller event sheets (perhaps 25 events each) for each layout?
They would probably both run at the same speed. However, for convenience sake, I would do one event sheet for the game and another for the menus, or something like that.
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They'd both run at the same speed, but you should prefer organising things in to different event sheets, just to make your game more manageable to work on!