You asked, so you get:
* Rabid dogs that fire bees at you when they bark at you
* Ninjas that rope down from the ceiling with boxcutters in hand
* One of the big bosses could be Lance Armstrong trying to jab you with a steroid needle
* As for gameplay mechanic, have you played Fez before? You could be inside of the house and as you progress through you get this pseudo 2D/3D level spin effect: en.wikipedia.org/wiki/Fez_(video_game)
My brain is fried at the moment, there you go though. Please put Lance Armstrong in there.