If it works with another mouse, it seems like the problem would have to be your laptop's mouse button..
To be sure, you should try to use your mouse in a different, but similar scenario. If you're holding down a key to run and clicking isn't working.. Try another html5 game where you need to hold down a key and click the mouse and see if that works.
Maybe the windows upgrade fudged up your mouse drivers? Might try updating them...
That's my best guess, anyway..