Zebbi Waltuo Linux and Mac OSX ports stopped working entirely for us towards the end of development, but our game was also over 500MB at export by that point and nearly 2000 files after all the art, sounds, and music was exported.
Greenworks (Steam achievements and overlay plugin) seems to be getting an update soon, but currently it still does not support the latest Node-JS versions at all it seems:
The platform behavior seems to have changed between v192 and new versions of Construct 2 which causes our player to be unable to jump at times or fall through floors. This may be because the project has gone through so many updates of C2/is so old that it perhaps is doing things differently to how Construct 2 wants to work now, but re-coding nearly 26,000 events is just not feasible (lots and lots of enemies, two player mode with multiple characters on top of the singleplayer mode, arcade mode and story mode, lots of levels, custom control binding, soundtrack selection, etc all add to that total).
Changing from Node-Webkit 10.5 to NodeJS for testing new releases we still notice the "jank"/lag issues and game logic glitches, so we end up reverting to NW10.5 for patches and updates to the game.
The biggest problem we have though is explaining these issues to customers. They don't understand why they have much better than "recommended specs" and get lag and jank and characters falling through floors, and the cause could be anything like "Your AMD GPU is high-powered but older than WebGL", "Your computer is running Google Chrome at the same time as the game", "You are running screen capture software/streaming it".
The issues will probably be unnoticed in most small to average sized games, but large games (aka: so large we had to hack our Windows registry to allow more UI handles), seem to be a real stretch to make work in Construct 2, and even more so to make them work at export (we had to change a few flags in NW10.5's exporter to also get a few frames more performance/work with Greenworks).
Also as a side note, WiiU doesn't support WebGL so it is quite a performance hit compared to desktops.